Integrative Therapeutics Motility Activator - 60 vegcaps

Research-based motility activator supplement

The main health benefit of Integrative Therapeutics Motility Activator is to support gastrointestinal motility and transport. The supplement combines a clinically studied proprietary blend of Pycrinil Artichoke (Cynara cardunculus) leaf extract and ginger (Zingiber officinale) root extract. This combination has been assessed and proven effective for digestive health in clinical trials. 

Comprehensive gastrointestinal health

This ginger and artichoke extract supplement can be used by both men and women to support gut health, gastric emptying or gut motility, gastrointestinal restoration and comfort.

• Well-tolerated
• Clinically-studied prokinetic agent.
• Contains a standardised extract of Cynara cardunculus
• Acts in a dose-dependent manner.
• Formulation is free from gluten, soy, wheat, artificial colours and flavours.

• Serving Size:1 Vegetable Capsule
• Servings Per Container:60
• Amount Per Serving
• Clinically Studied Proprietary Blend 100 mg
• Pycrinil® Artichoke (Cynara cardunculus) Leaf Extract
• Ginger (Zingiber officinale) Root Extract 20 mg
• Other Ingredients:

dicalcium phosphate, plant-derived capsule (hypromellose), cellulose, sodium croscarmellose, magnesium stearate, silica

Adults take 1 capsule twice daily, or as recommended by a healthcare professional.

Integrative therapeutics motility activator​ works due to the potent combination of two natural ingredients proven to support gastrointestinal motility. The combination is considered highly effective in managing digestive discomfort and gastric motility in healthy people who are troubled with digestive issues and are looking motility activator supplement to solve these problems.

Ginger and artichoke have been used traditionally for supporting good health.  Gingerols and shogaols are the active constituents of ginger. 

Cyanidin, cynaropicrin, tannins, caffeoylquinic acids, and luteolin are the main ingredients in Artichoke. Its leaf extract has a choleretic effect (stimulation of bile flow from the liver) due to cynarian content that majorly supports bile production and bile flow.

Artichoke extract has anti-spasmodic (relieves muscle spasms) and choleretic activity on the small bowel. 

The ginger facilitates gastric emptying by modulating cholinergic M3 and serotonergic 5- HT3/5-HT4 receptors. In other words, ginger is responsible for modulating serotonin signalling by additional 5-HT4 stimulation and by modulating 5-HT3 receptors in the enteric nervous system and brain stem, it supports gastric emptying, intestinal transit, healthy visceral sensation and helps maintain upper gastrointestinal comfort.

Functional dyspepsia is a type of chronic indigestion. Individuals suffering from this condition experience pain in the stomach, and a feeling of fullness or bloating during and after meals. A study included 126 cases of this condition found the combination of artichoke and ginger extract to be effective in reducing digestive symptoms by 34%. These symptoms included complaints like epigastric fullness, bloating and early satiety. Nearly 86% of these cases experience the digestive health benefit. This could be due to an improvement in intestinal transit and achievement of adequate intestinal function.

The benefits of ginger in Integrative therapeutics motility activator​ supplements are due to the presence of an active ingredient called gingerols. Ginger increases antral motility during phase III of the migrating motor complex or MMC during fasting and postprandially. Galanolactone is another active ingredient of ginger that works as an antagonist of illeal 5-HT receptors.

Integrative therapeutics motility activator​ is one of the highly popular supplements experts recommend. It can be a good option to experience comprehensive gastrointestinal health.

Speaking about Integrative motility activator side effects, studies have not highlighted any potentially harmful side effects. 

1. About gastrointestinal motility

The esophagus, stomach, and small and large intestine coordinate and work in collaboration to support digestion and motility. Hypo or hypercontractions of these cause a variety of gastrointestinal symptoms that badly affect the quality of one’s life. 

Common symptoms of dysmotility disorders are:

• Postprandial fullness
• early satiation
• Nausea and  vomiting
• Pain in abdomen
• bloating, 
• Dysphagia
• heartburn

2. About MMC

Migrating motor complexes or MMC are located in the stomach and the small bowel. It is a four-part complex. Every phase has varying degrees of contraction. Phase III is the most active. Motilin and 5-hydroxytryptamine control MMC. Any disturbance in serotonin signalling causes gastrointestinal discomfort. 

The length of this cycle varies between 113 to 230 minutes and depends on the phase III origin. For example, the MMC cycle length is longer when phase III originates in the antrum compared. An acidic pH also increases the length of MMC.

Phase I of MMC

The antral region will be in phase I constituting 50% of the entire MMC cycle length. In phase I, there are no contractions.

Phase II of MMC

The distal in the small intestine phase II constitutes approximately 80% of the MMC. the contractions are present but there are irregular intervals between consecutive contractions.

Phase III of MMC

This phase can begin either in the stomach or small intestine. In healthy individuals, it begins in the stomach. 

There is an increase in the frequency of high-pressure, peristaltic contractions over time until it reaches 2–3 contractions per minute in the stomach and 11–12 contractions per minute in the small intestine. The contractions propagate slowly as a band of high-amplitude peristaltic contractions down the entire length of the small intestine at a rate of ∼6–10 cm/min.

At the end of phase III, the phase I cycle begins again and continues until the next meal is consumed. 

3. How can you benefit from using ginger and artichoke extract supplements?

• Healthy digestion: Ginger(Zingiber Officinale) and artichoke (Cynara cardunculus) have been used traditionally and are known to promote healthy digestive function.
• Promote gastrointestinal restoration: This combination maintains a healthy balance between gut bacteria. 
• Improve gastric function: Studies have measured the effects of the combination of Cynara cardunculus and Zingiber officinale extracts on gastric function. The combination improves symptoms like nausea, fullness, satiety, bloating and stomach discomfort.
• Supports gastrointestinal motility:  Integrative therapeutics motility activator is a prokinetic agent that improves gastric motility and relieves digestive symptoms.
• Support MMC function: MMC or Migrating motor complex is a cyclic, recurring motility pattern in GIT and occurs in the stomach and small bowel. MMC is a mechanical and chemical cleansing of the empty stomach in preparation for the next meal.  It is a four-part complex with varying contractions within each phase. Phase 3 is considered to be the most active phase. Ginger increases antral motility during phase III of the MMC during fasting and after meals.
• Improve constipation: Constipation is when bowel movements are less frequent and stools become difficult to pass. There are many causes of constipation, like inadequate fibre intake, diet changes, etc. Integrative therapeutics motility activator relieves symptoms of constipation.
• Liver function: Artichoke leaf extracts contain cynarian, which exerts a choleretic effect and supports bile production and flow.
• Relieve nausea, bloating and other symptoms:  Research studies highlight that Artichoke completes the effects of ginger.  Artichoke acts on the small intestine, and ginger is active in the stomach. This combination improves symptoms like stomach pain, nausea, bloating and epigastric fullness.

Do not use if you have a bile duct obstruction, or if you are allergic to plants of the Asteraceae (Compositae) family, including ragweed.

If you are pregnant, nursing, have gallstones, or if you are taking prescription drugs, consult a healthcare professional before use.

1. How to take a motility activator? 

1-2 capsules can be taken at bedtime. When taken before bed, it works best because overnight fasting enables the MMC process. Prokinetics can even be taken alongside SIBO treatment. A motility activator by integrative therapeutics is taken one capsule twice daily.

2. What does a motility activator do? 

Motility activator consists of a blend of prokinetic agents that:

• restore intestinal motility
• promotes contractions in the migrating motor complex
• improve digestive health
• provide relief from symptoms of abdominal discomfort like gas and bloating.

3. When to take motility activator​?

You may take motility activator to improve digestive health in conditions like SIBO and get relief from symptoms like gas and bloating, constipation, etc. You can take it at bedtime. Always read the label of the product for more information.

4. What is gastrointestinal motility?

It refers to the movement of food from the mouth through the pharynx, esophagus, stomach, intestines, and out of the body (elimination). In short, it is the movement of the food through the gastrointestinal system by involving the coordination of smooth muscles, nerve functions and secretions of the stomach.

5. Does a motility activator give you gas?

No, instead it gives you relief from symptoms of abdominal discomfort like pain, bloating, gas, constipation, etc.

motilpro vs motility activator​

• Motilpor is a gut signalling support formula that supports gastrointestinal motility and upper GI discomfort. 1-3 capsules are taken one to two times daily in between meals. It has ginger extract  (from Zingiber officinale root), 5-Hydroxytryptophan (from Griffonia simplicifolia seed),  Pyridoxal-5-phosphate and acetyll-carnitine (from corn dextrose fermentation and palm oil)
• Motility activator supports gastrointestinal motility and transport. One such expert-recommended option is integrative therapeutics motility activator​ that contains a standardised extract of ginger and artichoke. 

6. How motility activator help sibo?

We know that MMC also helps clear debris (for eg, bacteria) from the small intestine into the large intestine. Due to MMC deficiency, bacteria accumulate in the small intestine and also bacteria travel from large intestine into the small intestine. This happens in SIBO.  Due to this, the affected individual starts experiencing huge gastrointestinal discomfort like bloating. 

Motility activator sibo affected person may take to support gut health.  MMC is defence mechanism against SIBO as it prevents SIBO, bloating and constipation.  To improve MMC, some of the useful tips are:

• Don't eat snacks between meals.
• Try to maintain a window period of 4-5 hours between meals.
• You may consult an expert to learn more about intermittent fasting.
• Work on your diet.
• Start eating healthy.
• Sleep well
• Manage stress levels
• An expert may recommend you take a motility activator. One such option is integrative therapeutics motility activator. The ingredients are natural and have been studied to be effective prokinetic agents.
• You may take a motility activator after finishing your antibiotic course, and discuss more with your healthcare provider.

7. What are the main functions of the gastrointestinal system?

The main benefits are:

• Food digestion
• Absorption of nutrients
• Enzyme secretion
• Excretion 

8. How to increase gastrointestinal motility​?

Here are some of the tips to boost gastrointestinal motility naturally:

• Do exercise daily for 30 minutes
• Add more fibre-rich food to your plate. Eat whole grains and leafy vegetables.
• Take fresh fruits daily
• Take probiotics. Either yoghurt or probiotic supplements are the best.
• Cut down on unhealthy dietary choices. Start avoiding white sugar, white flour, etc.
• Drink 8-10 glass water daily. Sip water throughout the day.
• Rely more on non-caffeinated teas and drinks. Fill 2 or 3 tall glass bottles with a total of 10 cups of water (can add flavour with cucumber slices, fresh mint or lemon juice), and sip the water throughout the day.