Calcium-d-Glucarate 1000 mg

A study published in Nutrients explained how Calcium D-glucarate works.

Calcium D-glucarate plays an essential role in eliminating products the liver has prepared for excretion. 

There are two phases of detoxification: Phase 1 and Phase 2. After phase 1, intermediate metabolites may be produced, so phase 2 detoxification is required to prepare them for easier elimination via the gut and kidneys. Toxins, Hormones, medications, metabolic byproducts and neurotransmitters are neutralised via phase II liver detoxification through different types of processes, including glucuronidation. It refers to conjugating or binding metabolite products in phase 1 to glucuronic acid. After binding, these are removed or excreted through bowel movement or the kidneys.

Colonocytes and some gut bacteria produce the beta-glucuronidase enzyme. It can inhibit the excretion of the harmful toxins or products that the liver has packaged up. These toxins also include estrogen metabolites. The role of this enzyme is to deconjugate metabolites, which are further reabsorbed by the gut. If any imbalance occurs in gut bacteria, it causes an increase in the number of beta-glucuronidase, which can further interfere with toxin and estrogen elimination. 

This clearly highlights the importance of inhibiting beta-glucuronidase activity. Here, the role of calcium D-glucarate comes into play. Most importantly, its inhibitory effect is considered to be the longest on beta-glucuronidase.

Calcium-d-Glucarate 1000 mg is one of the best options to consider if you are planning to buy a high-quality supplement containing calcium glutarate for detoxification.