Mitopure vs other supplements: Is Mitopure worth it?

Introduction

“Mitochondrial health” is often used as if all mitochondrial supplements do the same thing. They don't. “

Many supplements are marketed for mitochondrial health, longevity or anti-aging but they do not work in the same way. This distinction matters if you're comparing one supplement with the other. In this article, we have compared Mitopure with supplements such as NMN, CoQ10, magnesium or B vitamins.

We want our readers to understand that “Mitochondrial health isn't just about making more energy. It's also about maintaining and replacing dysfunctional mitochondria.”

How is Urolithin A different from other mitochondrial health supplements?

• Urolithin A has primarily been studied in relation to mitophagy, the cellular process involved in removing and recycling damaged mitochondria. In simple language, mitophagy means the clearance of damaged mitochondria while biogenesis means the creation of new mitochondria.

• CoQ10, NAD+ and B vitamins target energy production, meaning optimal functioning of mature mitochondria.

• NAD+ and Resveratrol target biogenesis.
  

Mitopure vs NMN: They don't target the same thing 

Talking about Mitopure:

Mitopure contains Urolithin A, which has been studied as a mitophagy activator. Mitophagy is a cellular quality-control process that helps remove and recycle damaged mitochondria. 

Mitopure improves mitochondrial function and has evidence of improved muscle strength and endurance in randomised controlled trials. Human research on Urolithin A has focused particularly on mitochondrial health and muscle-related outcomes. These supplements are expensive as well compared to NMN supplements.

A glimpse of consequences of mitochondrial dysfunction and the role of Urolithin A

Source: Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

Talking about NMN supplements:

NAD+ boosters raise NAD+ levels. The functional evidence is mixed across different trails. These target broad cellular metabolism and are comparatively cheaper compared to the Mitopure.

Is Mitopure worth the higher price? 

Mitopure may be worth considering if:

• Your primary focus is mitochondrial health.

• You are particularly interested in muscle health and physical performance. There can be many aspects to physical performance, like if your profession demands long standing hours or you are a trainer and want to boost performance, etc. 

• You believe in scientific research.

• You are health conscious and always want to know more about what you put inside your body. For supplements, you focus on ingredients, their quality, sourcing, etc.

• You are comfortable and find it worth investing in an evidence-based supplement.

• Your healthcare practitioner recommended this supplement.

Mitopure is not worth considering if:

• Your goal is specifically supporting NAD+ metabolism

• You are looking for an NMN supplement.

• Your focus is energy metabolism

• Cost is a major factor

• Your healthcare professional has recommended a specific nutrient based on your diet or circumstances
  

What Mitopure has NOT been proven to do?

• Urolithin A should not be used for treatment for aging, disease, muscle loss or mitochondrial disorders. 

• Research has investigated specific biological and physical outcomes.

• The findings from clinical trials does not mean supplementation has been proven to prevent or treat disease.

Which mitochondrial supplement targets what? 

Note: 

• These ingredients are not interchangeable, and evidence for one should not automatically be applied to another. 

• Relevance does not mean proven superiority. The appropriate choice depends on the specific goal, evidence, cost and individual circumstances 

Final words

If your primary interest is NAD+ levels, NMN belongs in that conversation. If your primary interest is research on Urolithin A, mitochondrial quality control and muscle-related outcomes, Urolithin A may be particularly relevant to investigate 

Consult your healthcare provider before starting any supplement.

References:

• Singh A, D'Amico D, Andreux PA, et al. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Rep Med. 2022;3(5):100633. doi:10.1016/j.xcrm.2022.100633 

• Shade C. The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule. Integr Med (Encinitas). 2020;19(1):12-14. 

• Okabe K, Yaku K, Uchida Y, et al. Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects. Front Nutr. 2022;9:868640. Published 2022 Apr 11. doi:10.3389/fnut.2022.868640 

• Andreux PA, Blanco-Bose W, Ryu D, Burdet F, Ibberson M, Aebischer P, Auwerx J, Singh A, Rinsch C. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nat Metab. 2019 Jun;1(6):595-603. doi: 10.1038/s42255-019-0073-4. Epub 2019 Jun 14. PMID: 32694802. 
  

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