Supports mood, liver, and methylation health through
carefully-formulated nutrient support.* What It Does SAMe with Cofactors
provides targeted nutritional support for balanced mood, healthy liver
function, and optimal methylation activity.* This comprehensive formula
combines S-adenosyl-L-methionine (SAMe) with essential methyl donors and
cofactors including vitamin B6, active folate, and methylcobalamin to help
sustain neurotransmitter synthesis, cellular detoxification, and energy
metabolism.* How It Works SAMe (S-adenosyl-L-methionine) — Serves as a
universal methyl donor that supports serotonin, dopamine, and norepinephrine
metabolism while promoting liver detoxification and phospholipid synthesis.*
[1,2] L-5-Methylfolate — Provides the biologically active form of folate,
essential for the remethylation of homocysteine and production of
neurotransmitters involved in mood regulation.* [3,4] Vitamin B12 (as
methylcobalamin) — Works with folate and SAMe to maintain methylation balance,
support nerve integrity, and aid in red blood cell formation.* [4,5] Vitamin B6
(as pyridoxal-5′-phosphate) — Functions as a coenzyme in amino acid metabolism and
assists in the synthesis of serotonin, GABA, and dopamine.* [5] Who It’s For Ideal
for individuals seeking support for mood balance, cognitive clarity, and liver
function, or those with increased methylation demands due to stress, genetic
polymorphisms, or other situations.* Special Features Features the active,
bioavailable forms of B-vitamins including methylcobalamin, L-5-MTHF, and P-5-P
for immediate utilization, with 400 mg of SAMe to optimize methylation
efficiency. Free of gluten, soy, and manufactured under strict quality
standards for purity and strength.* References 1. Baden KER, et al. Nutrients.
2024;16(18):3148. doi:10.3390/nu16183148 2. Baden K, et al. Nutrients.
2024;16(21):3668. doi:10.3390/nu16213668 3. Papakostas GI, et al. Am J
Psychiatry. 2012;169(12):1267-74. 4. Reynolds E. Lancet Neurol.
2006;5(11):949-60. 5. Kennedy DO. Nutrients. 2016;8(2):68.
