This formula is an optimal methylation formula with
activating co-factor created by Kendal Stewart, MD to support the methylation
pathway and provide adequate folinic acid and methyl folate (5-MTHF). This
product is designed to be used in conjunction with the Methylation Complete
Fast Dissolves OR Methylation Pro Topical that provides the activating B12
co-factors to deliver the additional tetrahydrofolate to support neurological
and immune recovery. For those who have high folic acid levels in the blood
plasma, then it can be assumed that folate is not being converted and entering
the nervous sytem, immune system and blood brain barrier. Most often poor
methylators will need additional folate. The addition of Niacinamide helps
support the mitochondria and supports as a cofactor for the delivery of the
other ingredients in Methyl Folate Plus. The typical indications for this
product include but are not limited to:* Presence of Folate Receptor Autoantibodies.
*Homozygous (2 copies) MTHFR polymorphism. *Increased requirement for
development (age 8-20). *Acute recovery from major neurological injuries.
*Moderate to severe autism related issues. *Poor recovery from surgery or
injury. Folinic acid (also known as Leucovorin) is a 5-formyl derivative of
tetrahydrofolic acid. It is readily converted to other reduced folic acid
derivatives (e.g., tetrahydrofolate), and, thus, has vitamin activity that is
equivalent to that of folic acid. 5-MTHF (L-Methyl tetrahydrofolate) is
involved in neurotransmitter synthesis and critical enzymatic reactions
throughout the body. Folate benefits cardiovascular health and nervous system
function. Ordinary folic acid supplements may not deliver the full spectrum of
effects. This is due to the fact that once ingested, not everyone converts the
usual folic acid supplements to their biologically active form called
5-methyltetrahydrofolate (5-MTHF). Methyl Folate Plus provides 5-MTHF in its
active form. Recent studies have shown that a significant portion of the
population have genetic enzyme deficiencies which prevent the conversion by
methylation of folate to 5-MTHF. 5-MTHF has been shown to be up to seven times
more bioavailable than regular folic acid. This greater bioavailability is
especially important in people who have a genetic enzyme deficiency since it
requires no conversion to become metabolically active. 5-MTHF is able to cross
the blood-brain barrier to enhance brain synthesis of acetylcholine—the
neurotransmitter associated with memory, which is especially important for
people with cognitive difficulties and neuro-immune syndromes. Frequently asked
question: Is 5-MTHF the same as L-Methylfolate? It is. We use two types of
MTHF, one stabilized with calcium and one stabilized with glucosamine
(non-shellfish-derived). Both are synonymous with L-Methylfolate. Special
Considerations: People with MTHFR & FLOR SNPs benefit greatly from taking
methylfolate. Always take Methyl B12 with methylfolate, as it is a needed
cofactor in methylation. Niacinamide does not cause flushing at any dose.
However, it is readily converted to an enzyme called NADH that is needed for
metabolism and energy production to support mitochondrial health. Unlike other
vitamins, the body is able to make its own niacinamide using tryptophan as the
raw material. Tryptophan is an amino acid the body also uses to make serotonin,
a critical neurotransmitter for moods, sometimes referred to as the “happy
brain chemical.” Since tryptophan is often in short supply in the body, taking
niacinamide can help spare it and make more available for serotonin production.
As a result, niacinamide has complex and supportive interactions with body and
brain function as well as a wide range of benefits. Vitamin B2
(Riboflavin-5-Phosphate) Riboflavin is critical for normal growth and repair.
It is needed to facilitate normal reproduction, cell growth and repair, and
development of tissues. The body utilizes vitamin B2 to keep tissue health and
to help accelerate healing of injuries. Riboflavin acts to help the immune
system to function properly by reinforcing the body's reserve of antibodies
which guard against infection. Along with other B Vitamins, Vitamin B2 helps
protect the nervous system. It could be an essential component of treating
various nervous system issues, including nervousness, numbness and tingling and
poor memory.
