• Metagenics SPM Active 120 softgels specialized pro-resolving mediators supplement bottle
  • Metagenics SPM Active 60 softgels specialized pro-resolving mediators supplement bottle
  • Metagenics SPM Active supplement facts with fractionated marine lipid concentrate and SPMs
Metagenics

SPM Active

$75.95
$75.95
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UPC : 755571952295,755571952301

SPM Active combines specialized pro-resolving mediators from a fractionated marine lipid concentrate in convenient softgels for easy daily nutritional supplementation and use.
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  • Contains SPMs
  • Softgel format
  • Product carries TrustScore from SuppCo

Serving Size: 2 Softgels

Servings Per Container: 30

Ingredients

Amount Per Serving

Calories

10

Total Fat

1 g

Cholesterol

<5 mg

Active Fractionated Marine Lipid Concentrate SPM content standardized to 18-hydroxy-eicosapentaenoic acid (18-HEPE) 17-hydroxy-docosahexaenoic acid (17-HDHA) and 14-hydroxy-docosahexaenoic acid (14-HDHA).

1 g

Other Ingredients: Fractionated marine lipid concentrate [fish oil (anchovy, sardine, and mackerel) and mixed tocopherols (antioxidant)], softgel shell (gelatin, glycerin,and water), and silica. Contains: Fish (anchovy, sardine, and mackerel).

Adults can take two softgels once daily or as directed by a healthcare practitioner. If you are pregnant, nursing, or taking medication, consult with a healthcare provider before use. 

Quality & Sourcing

Metagenics manufactures its supplements in GMP-certified facilities using science-backed ingredients. The company performs 200K+ tests annually starting from ingredient sourcing to the final products. According to the brand’s quality promise, their products are triple tested during three stages: ingredient, formula, and encapsulation for identity, purity, stability, and strength. Being a registered B Corporation, the company also follows sustainable practices.

Why Buy from Nutriessential

Nutriessential sources all its supplements directly from manufacturers. You can get fresh and authentic supplements when you place your order. Connect with our healthcare experts to know more. 

Caution: If pregnant, nursing, or taking nutritional supplements or medications, consult your healthcare practitioner before use. Keep out of the reach of children.

Storage: Keep tightly closed in a cool, dry place. Do not use it if the safety seal is missing or broken.

Dietary Considerations-

  • Gluten-Free
  • Non-GMO
  • Contains Fish (anchovy, sardine, and mackerel).

The Specialized Pro-resolving Mediators (SPMs) are natural lipid molecules. They are derived from omega-3 and omega-6 fatty acids. In a 2025 review published in The Knee Journal, researchers studied the role of SPMs in association with chronic inflammation following knee injuries. The review discusses the biological processes involved in the resolution of inflammation and the role of pro-resolving molecules such as SPMs. 

Metagenics SPM Active provides SPMs derived from omega-3 fish oil. They are different from EPA and DHA you get from any fish oil supplement. The body makes SPMs from fish oils and this supplement provides this pre-converted SPM nutrient directly. 

An open-label trial was conducted in 2020 to evaluate the use of SPM Active softgel formulation in adults over 4 weeks. Researchers observed statistically significant improvements in pain intensity, daily pain interference, and mood. The authors noted that further placebo-controlled clinical trials are necessary. 

Product Description

SPM Active from Metagenics is a softgel capsule that contains specialized pro-resolving mediators (SPMs). These are concentrated nutrients from omega-3 fish oil.

1. What are SPMs?

SPMs are natural compounds produced by the body. Metagenics SPM Active provides SPMs directly through 2 softgels. 

2. How long will it take to notice a difference with Metagenics SPM Active?

Individual responses vary. In the open-label clinical trial involving Metagenics SPM Active, researchers observed improvements in pain-related measures by week 2. The authors noted that further placebo-controlled clinical trials are necessary.

Disclaimer

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Product descriptions are based on information provided by the manufacturer. This information reflects general manufacturer guidance and should not replace advice from a qualified healthcare professional.