Cinnulin PF® (Cinnamon Bark Extract) — 125 mg A patented, water-soluble extract of Cinnamomum cassia bark (US Patent #7,504,118 & #8,003,141) concentrated in bioactive Type-A doubly-linked polyphenols. Unlike fat-soluble cinnamon compounds associated with hepatotoxicity risk, Cinnulin PF® is specifically processed to remove potentially harmful cinnamaldehyde and coumarin fractions, yielding a purer, safer extract. Supports insulin receptor substrate phosphorylation and promotes GLUT4-mediated intracellular glucose uptake, helping to maintain healthy glucose management and insulin utilization by cells.
Chromemate® Chromium Polynicotinate — 200 mcg A patented niacin-bound form of chromium recognized for superior bioavailability and cellular uptake compared to chromium picolinate and chromium chloride forms. Chromium is an essential trace mineral cofactor in the activity of the glucose tolerance factor (GTF) complex, which potentiates insulin receptor signaling and supports efficient intracellular glucose metabolism. Helps maintain blood sugar levels already within the normal range and promotes appropriate cellular insulin response.
Gymnema sylvestre Leaf Extract — 200 mg (yielding 50 mg Gymnemic Acids) Standardized to 25% gymnemic acids — the primary bioactive triterpenoid saponins responsible for this herb's clinically recognized activity. Gymnemic acids share structural similarity to glucose molecules and competitively inhibit intestinal glucose absorption at the brush border epithelium. Additionally, Gymnema sylvestre supports pancreatic beta-cell integrity and promotes normal insulin secretion, contributing to healthy postprandial glucose regulation and reduced carbohydrate craving signaling.
Alpha-Lipoic Acid — 100 mg A naturally occurring, mitochondria-centered dithiol antioxidant uniquely soluble in both aqueous and lipid environments, providing broad-spectrum free radical scavenging across cellular compartments. Functions as an essential cofactor in the pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase enzyme complexes, directly supporting mitochondrial energy production from glucose substrates. Additionally supports the regeneration of endogenous antioxidants including glutathione, vitamin C, and vitamin E, helping to attenuate oxidative stress associated with glucose metabolism dysregulation.
Bitter Melon (Momordica charantia) Extract — 80 mg (yielding 0.4 mg Charantin) Standardized to charantin, a steroidal glycoside with documented insulin-mimetic activity. Bitter melon contains multiple bioactive constituents — including charantin, polypeptide-p, and vicine — that collectively support glucose uptake in peripheral tissues and help maintain blood glucose levels already within the normal range. Provides complementary insulin-sensitizing activity alongside the formula's botanical and mineral components, supporting a multi-targeted approach to healthy glucose homeostasis.
Lagerstroemia speciosa L. (Banaba Leaf) Extract — 50 mg (yielding 0.5 mg Corosolic Acid) Standardized to corosolic acid, the principal bioactive triterpenoid in Banaba leaf with well-characterized glucose transport-facilitating activity. Corosolic acid promotes GLUT4 transporter translocation to the cell surface, enhancing insulin-stimulated glucose uptake in muscle and adipose tissue. Additionally, Banaba leaf constituents have demonstrated inhibitory activity at the level of intestinal alpha-glucosidase, supporting attenuated postprandial glucose excursion.
Vanadyl Sulfate — 5 mg An inorganic vanadium salt representing one of the most studied forms of the trace element vanadium in the context of glucose metabolism. Vanadyl sulfate has demonstrated the ability to suppress excessive hepatic glucose production and promote modest improvements in peripheral, insulin-mediated glucose disposal in human clinical studies. Functions as an insulin-mimetic agent at the post-receptor level, supporting intracellular signaling cascades involved in glucose uptake independent of direct insulin receptor binding.
