DIM® (Diindolylmethane) — 100 mg DIM® is a registered trademark of BioResponse LLC (US Patent #6,086,915), delivering diindolylmethane — the primary bioactive indole metabolite of cruciferous vegetable indole-3-carbinol — within a proprietary enhanced-bioavailability complex of starch, Vitamin E as tocophersolan, phosphatidylcholine, and silica that substantially improves the oral absorption of this inherently lipophilic, poorly water-soluble compound. DIM® modulates hepatic cytochrome P450 1A1 and 1A2 enzyme activity to promote the 2-hydroxylation pathway of estrogen metabolism — shifting the critical estrogen metabolite ratio toward the more favorable 2-hydroxyestrone (2-OHE1) and away from the more biologically potent 16α-hydroxyestrone — a shift with established clinical relevance for breast tissue health, prostate health, and overall hormonal balance in both male and female clients. At 100 mg per serving, DIM® delivers a clinically meaningful dose to support favorable estrogen metabolite balance, cellular health and division signaling, lean body composition support through estrogen repartitioning, and healthy aromatase activity regulation.
HMRlignan™ (Norway Spruce Picea abies Standardized Lignan Extract) — 30 mg HMRlignan™ is a trademark ingredient used under sublicense from Linnea S.A., providing 7-hydroxymatairesinol (7-HMR) — a plant lignan extracted from the knot wood of Norway Spruce (Picea abies) and among the richest known natural sources of this secoisolariciresinol-class lignan compound. Following oral ingestion, 7-HMR is efficiently converted by gut microbiota to enterolactone — a mammalian phytoestrogen with established selective estrogen receptor modulator (SERM)-like activity that competitively modulates estrogen receptor binding, promotes favorable estrogen elimination pathways, and works synergistically with DIM® to ensure that metabolized estrogen is directed through glucuronidation-dependent elimination channels rather than recirculated through enterohepatic recycling. HMRlignan™ provides a novel and complementary estrogen metabolism optimization mechanism to DIM® — addressing the elimination phase of estrogen clearance while DIM® addresses the metabolic pathway direction phase — creating a comprehensive two-stage estrogen metabolism support approach within a single formula.
Green Tea (Camellia sinensis) Leaf Extract — 250 mg (yielding 175 mg EGCG) Green Tea leaf extract, standardized to yield 175 mg of EGCG (epigallocatechin-3-gallate) per serving, provides the most concentrated polyphenol catechin fraction from Camellia sinensis — the primary bioactive compound responsible for green tea's well-characterized hormonal balance, antioxidant, and cellular health activities. EGCG has been identified as the most pharmacologically active agent in green tea with respect to hormonal metabolism — promoting higher levels of sex hormone binding globulin (SHBG) to reduce the proportion of free testosterone available for DHT conversion via 5-alpha reductase, and supporting healthy aromatase regulation to maintain appropriate testosterone-to-estrogen balance in both sexes. EGCG's established activity at key signaling pathways governing cellular division — including EGFR, PI3K/Akt, and MAPK pathway modulation — supports healthy cell cycle regulation in hormone-sensitive breast and prostate tissue, providing cellular protective activity that complements the estrogen metabolite pathway optimization of DIM® and HMRlignan™.
Calcium D-Glucarate (as Calcium D-Glucarate delivering 50 mg Calcium) Calcium D-Glucarate is the calcium salt of D-glucaric acid — a naturally occurring compound present in many fruits and vegetables — that supports the glucuronidation detoxification pathway, one of the primary Phase II hepatic conjugation routes through which the liver packages estrogen, environmental xenoestrogens, and other lipophilic toxins for safe biliary elimination. Its primary mechanism involves inhibition of beta-glucuronidase — a bacterial and hepatic enzyme that cleaves glucuronide conjugates in the intestine and liver, allowing conjugated estrogen and toxins to be deconjugated and reabsorbed rather than excreted — effectively preserving the integrity of the glucuronidation elimination pathway and ensuring that metabolized estrogen and environmental substances complete their full excretion pathway. This beta-glucuronidase inhibitory activity positions Calcium D-Glucarate as the detoxification complement to DIM® and HMRlignan™'s metabolic pathway-directing activity, comprehensively supporting the full arc of estrogen processing from hepatic metabolism through final intestinal elimination.
Trans-Resveratrol — 50 mg (from Polygonum cuspidatum Root Extract) Trans-resveratrol — the biologically active stilbene polyphenol isomer from Japanese Knotweed root — provides complementary hormonal balance support through selective aromatase enzyme inhibition, reducing the conversion of androgens to estrogens in peripheral adipose and adrenal tissue and supporting healthy testosterone-to-estrogen ratios in both men and women. Its polyphenolic antioxidant activity and SIRT1 activation contribute to cardiovascular endothelial protection, healthy LDL oxidation balance, and cellular senescence pathway modulation through mechanisms that complement the formula's EGCG and Vitamin E antioxidant contributions. As a phytoestrogen with selective estrogen receptor beta (ERβ) affinity — the receptor subtype preferentially expressed in bone and the cardiovascular system — trans-resveratrol supports bone mineralization and cardiovascular endothelial health alongside its hormonal metabolism activity, providing multi-system benefit that extends the formula's clinical relevance beyond purely hormonal applications.
