Product Description

Seeking Health Methyl B12 With L-Methylfolate provides methylated B12 and folate to enable your body to absorb these essential B vitamins better. The bioavailability of methylated vitamins is better than that of synthetic forms.

B vitamins are important for both physical and mental wellbeing. They support energy production and DNA production and repair. For a positive mood and healthy cognition, your brain needs these crucial vitamins. You may get these from your diet, but a minor deficiency may also cause a significant impact on your health.

Not everyone can metabolize synthetic forms of B vitamins. Some people may have the MTHFR gene variant, which interferes with your body's natural ability to convert folate and B12 into methylated forms for the methylation cycle. Methyl B12 with L-Methylfolate lozenges from Seeking Health provide these methylated forms directly, so that they can be readily absorbed. 

Research Evidence 

  • In a randomized controlled trial published in the Nutrients journal (2024), methylfolate and methylcobalamin (along with pyridoxal-5′-phosphate) helped reduce homocysteine levels in people with MTHFR, MTR, and MTRR gene polymorphisms. This study highlights the importance of personalized interventions for susceptible populations. 
  • Compared to only folic acid supplement, women who were given vitamin B complex (methylfolate, B12, and B6) were found to have better clinical pregnancy and birth outcomes. 
  • Methylfolate may cross the blood brain barrier and reach the central nervous system. This is useful for neural transmitter synthesis. 
  • Recent clinical trials have investigated the use of L-methylfolate for depression symptoms. It was found to be safe and well-tolerated. 

Seeking Health Methyl B12 With L-Methylfolate provides folate as True Folate (Quatrefolic), which features folate in bioavailable forms: methylfolate and folinic acid. Folinic acid is a methyl free form of folate that’s also readily absorbed by the body. Both these forms are easily absorbed by those with the MTHFR variant. It supports mood, DNA/RNA synthesis, cognition, fetal development, and genetic expression. 

Bioavailable B12 is present as MecobalActive. It includes Adeno and methyl forms of vitamin B12. Your body can use them readily. They are coenzymes for crucial enzyme actions. B12 promotes healthy energy production and detoxification. Further, the methylated form supplies methyl donors for a complete and efficient methylation process. 

1. What is methyl B12 and L-methylfolate good for?

Methyl B12 and L-methylfolate are active forms of vitamins B12 and B9, that your body can use directly. They are important for the methylation cycle. For those with MTHFR gene variation, supplementing with Seeking Health Methyl B12 With L-Methylfolate is more effective because their bodies have trouble converting inactive forms like folic acid (B9) and cyanocobalamin (B12). These methylated B vitamins are used for energy production and support brain function, mood, pregnancy, DNA synthesis and repair, and cardiovascular health.

2. What happens when you start taking methylfolate?

Your experience when you start taking methylfolate may vary. Those with compromised methylation cycle may be able to see the differences like increased energy, better mood, and mental clarity. Some people may have mild methyl B12 with l-methylfolate side effects like mood changes, sleep disturbances, muscle aches, etcm which can happen as your body adapts. According to Seeking Health Methyl B12 With L-Methylfolate reviews, people felt that their energy levels were improved in a few weeks of taking this supplement.

3. Does methylfolate detox the body?

Seeking Health Methyl B12 With L-Methylfolate supports the body's natural detoxification process. However, it's not a specific detox supplement. By providing methyl groups and supporting methylation, methylfolate in this supplement can help your body naturally eliminate harmful substances. 

4. Is it better to take methylfolate in the morning or at night?

You can start with ½ Seeking Health Methyl B12 With L-Methylfolate in the day time for the first week. Later, you can take up to 1 full lozenge. It's better not to take this supplement 5 hours before bedtime or at night, as it may interfere with sleep.