Multi-faceted botanical compound that supports healthy blood sugar metabolism, cardiovascular wellness, and GI health
- Promotes enhanced glucose and insulin metabolism
- Helps maintain healthy cholesterol levels
- Supports healthy metabolic function
- Promotes intestinal health
Berberine is a botanical compound found in plants including barberry, goldenseal, Oregon grape, and tree turmeric. Used in Ayurvedic and Chinese Medicine for hundreds of years, berberines diverse benefits and mechanisms of action are also supported in modern research. Its primary mechanism is its ability to activate the enzyme Adenosine Monophosphate-Activated Protein Kinase (AMPK) while inhibiting Protein-Tyrosine Phosphatase 1B (PTP1B).
Clinical evidence shows that Berberine may help to support and promote glucose and lipid metabolism. Berberine is also an anti-bacterial and it may help to protect the gastrointestinal system from infections. Further, it promotes cellular antioxidant defense and exhibits anti-inflammatory effects.
Patient One Berberine supplies 500 mg berberine HCl per capsule, the dosage used in clinical trials for glucose and lipid control.
- Berberine has been shown to lower total and LDL cholesterol among diabetic participants in several controlled trials.
- In controlled trials berberine reduced HbA1c levels in diabetic participants with comparable efficacy to metformin. Among participants with the metabolic syndrome berberine has been shown to reduce waist circumference and body weight, blood pressure, triglycerides, and improve insulin resistance compared to placebo, with similar benefits in women with Polycystic Ovary Syndrome (PCOS).
- A clinical trial comparing standard therapy with or without berberine among patients receiving percutaneous coronary intervention showed improvements in multiple inflammatory markers.
- Vuddanda PR, Chakraborty S, Singh S. Berberine: a potential phytochemical with multi spectrum therapeutic activities. Expert Opin Investig Drugs. 2010 Oct;19(10):1297-307. [PMID: 20836620]
- Yu HH, Kim KJ, Cha JD, et al. Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus. J Med Food. 2005 Winter;8(4):454-61. [PMID: 16379555]
- Puertollano MA, Puertollano E, de Cienfuegos GÁ, et al. Dietary antioxidants: immunity and host defense. Curr Top Med Chem. 2011;11(14):1752-66. [PMID: 21506934]
- Zou K, Li Z, Zhang Y, Zhang HY, Li B, et al. Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system. Acta Pharm Sinica. 2016. [advance online pub accessed 12.5.2016].
- Jayaprakasha GK, Girennavar B, Patil BS. Radical scavenging activities of Rio Red grapefruits and Sour orange fruit extracts in different in vitro model systems. Bioresour Techno. 2008 Jul;99(10):4484-94. [PMID: 17935981]
- Manthey JA. Biological properties of flavonoids pertaining to inflammation. Microcirculation. 2000;7(6 Pt 2):S29-34. [PMID: 11151968]
- Ye L, Liang S, Guo C, et al. Inhibition of M1 macrophage activation in adipose tissue by berberine improves insulin resistance. Life Sci. 2016 Dec 1;166-82-91.
- Zhang Y, Li X, Zou D, Liu W, Yang J, et al. Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine.
Take 1 capsule 1-2 times daily as a dietary supplement, preferably with a meal or shortly after, or as directed by a healthcare professional.
Serving Size: 1 Capsule
Amount Per Serving
Berberine Hcl ... 500mg
(from Indian Barberry extract) (Berberis aristata root)
Other Ingredients: vegetable cellulose (capsule), l-leucine, rice flour
This product is free of milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, sugar, and artificial sweeteners, flavors, colors and preservatives.
This product is free of ingredients derived from genetically modified organisms (GMOs).
You may return most new, unopened items within 30 days of delivery for a full refund. We'll also pay the return shipping costs if the return is a result of our error (you received an incorrect or defective item, etc.).
You should expect to receive your refund within four weeks of giving your package to the return shipper, however, in many cases you will receive a refund more quickly. This time period includes the transit time for us to receive your return from the shipper (5 to 10 business days), the time it takes us to process your return once we receive it (3 to 5 business days), and the time it takes your bank to process our refund request (5 to 10 business days).
If you need to return an item, simply login to your account, view the order using the 'Complete Orders' link under the My Account menu and click the Return Item(s) button. We'll notify you via e-mail of your refund once we've received and processed the returned item.
We can ship to virtually any address in the world. Note that there are restrictions on some products, and some products cannot be shipped to international destinations.
When you place an order, we will estimate shipping and delivery dates for you based on the availability of your items and the shipping options you choose. Depending on the shipping provider you choose, shipping date estimates may appear on the shipping quotes page.
Please also note that the shipping rates for many items we sell are weight-based. The weight of any such item can be found on its detail page. To reflect the policies of the shipping companies we use, all weights will be rounded up to the next full pound.